Tag Archives: Paroxetine

Medical research proven to be mostly flawed

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Source::http://www.naturalnews.com/031121_medical_research_fraud.html#ixzz1D4pdk4NB

Thursday, January 27, 2011 by: Alexander Frantzis, citizen journalist

(NaturalNews) Internationally recognized as the foremost expert in assessing the credibility of medical research, Dr. John Ioannidis made a most disturbing discovery. Up to 90 percent of published medical information directly relied on by doctors to determine treatment is misleading, exaggerated, or quite often flat out wrong. Even more unsettling, the medical community agrees with his assessment.

Starting his medical career at the beginning of the evidence based medicine movement, Ioannidis gravitated away from undertaking new research towards assessing the validity of previous research. Systemic inaccuracy emerged consistently at every level, and began to paint the picture that most studies were biased. Uniquely positioned as an expert statistician, Ioannidis carefully assembled a team, which spent a decade exploring the problem before publishing a landmark paper. It concluded:

With natural levels of researcher bias, generally imperfect research techniques, and a common tendency to focus on novel rather than plausible theories, wrong findings will be the norm. At the same time the scientific journals are strongly biased towards publishing the most novel claims and lack effective safeguards for filtering out inaccurate studies.

The paper showed both theoretically and empirically that 80 percent of non-randomized studies (the most common type), 25 percent of the “gold-standard” randomized trials, and nearly 10 percent of the “platinum-standard” large randomized trials were incorrectly executed.

To highlight the inability to weed out bad research, they focused on the 49 most highly regarded and cited research papers published in the past 13 years. Of those, 41% had later been disproved when tested, while 24% hadn’t even been retested. Upon further examination, 3 of these studies, which were later firmly disproved, they found scientists were more likely to cite the original inaccurate study, in one case for at least 12 years after it was discredited.

Economics appears to be an underlying cause of the research inaccuracies. A successful scientific career depends upon your research being funded and published. This intellectual conflict of interest motivates scientists to pursue and produce results that will be funded. Scientific journals are naturally biased towards publishing new, exciting research; they rely upon a vetted peer review process that is frequently commandeered by scientists in pursuit of career advancement. Worst of all are drug studies, funded by pharmaceutical companies and commonly corrupted by a much stronger financial conflict of interest.

It thus should come as no surprise that many medications originally shown to be both safe and effective in numerous large randomized control trials were later found to be dangerous. Vioxx, Zelnorm, and Baycol all were taken off the market for safety concerns, while the anti-depressants Prozac, Zoloft, and Paxil are now known to be no more effective than placebos.

Science, by definition, relies upon continual retesting of previous results by other scientists to protect against erroneous conclusions. Yet, this does not occur. In Ioannidis’ own words, the“odds that anything useful will survive from any of these studies are poor.”

Sources:
http://www.theatlantic.com/magazine…

http://www.plosmedicine.org/article…

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Study reveals top ten violence-inducing prescription drugs

As most who read this know-I would tend toward a more conspiratorial view of this. Our government has often experimented on us with drugs and I suspect they have known about this.  http://www.naturalnews.com/029946_government_conspiracy_medical_experiments.html

Notice that the smoking cessation drug Chantix is # 1 and that the US and local governments have been HEAVILY pushing people to stop smoking through their heavy handed criminalization of smoking everywhere even in people’s own homes. http://www.mercurynews.com/bay-area-news/ci_16417771?source=rss&nclick_check=1

Don’t think for 1 minute that they do not want an increase in violence as an excuse to further restrict your rights and freedoms. (E) http://www.truthandliberty.com/ProblemReactionSolution.html and https://ephraiyim.wordpress.com/the-problem-reaction-solution-paradigm-why-911-happened/

Here is the PLOS research article:  http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015337

drug

Saturday, January 15, 2011 by: Ethan A. Huff, staff writer

 

(NaturalNews) The Institute for Safe Medication Practices (ISMP) recently published a study in the journalPLoS Onehighlighting the worst prescription drug offenders that cause patients to become violent. Among the top-ten most dangerous are the antidepressants Pristiq (desvenlafaxine), Paxil (paroxetine) and Prozac (fluoxetine).

Concerns about the extreme negative side effects of many popular antidepressant and antipsychotic drugs have been on the rise, as these drugs not only cause severe health problems to users, but also pose a significant threat to society. The ISMP report indicates that, according to the U.S. Food and Drug Administration‘s (FDA) Adverse Event Reporting System, many popular drugs are linked even to homicides.

Most of the drugs in the top ten most dangerous are antidepressants, but also included are an insomnia medication, an attention-deficit hyperactivity disorder (ADHD) drug, a malaria drug and an anti-smoking medication.

As reported inTime, the top ten list is as follows:

10. Desvenlafaxine (Pristiq) – An antidepressant that affects serotonin and noradrenaline. The drug is        7.9 times more likely to be associated withviolencethan other drugs.

9. Venlafaxine (Effexor) – An antidepressant that treats anxiety disorders. The drug is 8.3 times more     likely to be associated with violence than other drugs.

8. Fluvoxamine (Luvox) – A selective serotonin reuptake inhibitor (SSRI) drug that is 8.4 times more       likely to be associated with violence than other drugs.

7. Triazolam (Halcion) – A benzodiazepine drug for insomnia that is 8.7 times more likely to be                   associated with violence than other drugs.

6. Atomoxetine (Strattera) – An ADHD drug that is 9 times more likely to be associated with violence       than other drugs.

5. Mefoquine (Lariam) – A malaria drug that is 9.5 times more likely to be associated with violence           than other drugs.

4. Amphetamines – This general class of ADHD drug is 9.6 times more likely to be associated with             violence than other drugs.

3. Paroxetine (Paxil) – An SSRI antidepressant drug that is 10.3 times more likely to be associated            with violence than other drugs. It is also linked to severe withdrawal symptoms and birth defects.

2. Fluoxetine (Prozac) – A popular SSRI antidepressant drug that is 10.9 times more likely to be               associated with violence than other drugs.

1. Varenicline (Chantix) – An anti-smoking drug that is a shocking 18 times more likely to be                       associated with violence than other drugs.

Sources for this story include:

http://healthland.time.com/2011/01/…

 

 


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